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The G6PD-d HUVECs also demonstrated increased expression of VCAM/ICAM-1, TGF and other pro-inflammatory molecules such as TNF and MCP-1

Current Research on Biosciences and Biotechnology, 4 (1), 242245

Elevated levels of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), directly interfere with insulin receptor signaling in peripheral tissues

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